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Finally, long IVCT and IVRT also prolong the potential for mitral regurgitation to occur while blood is not being ejected forward, thus worsening the balance of blood ejected forward versus backwards from the ventricle.
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The relatively long stopover periods enabled prolonged contact of migratory ducks with local domestic and wild bird populations or through shared water, thus prolonging the potential for virus transmission.
α-Toxins from scorpion venoms prolong the action potential of excitable cells by blocking sodium channel inactivation.
However, studies published in the past decade have highlighted the influence of substrate elasticity on stem cell fate and revealed that culture on a soft hydrogel substrate can promote self-renewal and prolong the regenerative potential of muscle stem cells.
Our findings showed that an appreciable number of compounds did not affect the hERG channel, but did prolong the action potential duration (APD).
This is shown in greater detail in the expanded records of Figure 6 C. The initial effect of applying 500 µM caffeine was to increase the SR Ca depletion and prolong the action potential (trace i).
Antiarrhythmic drugs that prolong the atrial action potential can assist in the prevention of recurrent AF by promoting the reversal of electrical remodeling.
hERG channel blockers delay repolarization, which prolongs the action potential duration (APD), and this translates into a prolongation of the QT interval.
The depression of calcium uptake activity delays the inward calcium current, thus prolonging the action potential duration resulting in myocardial conduction delay.
Overexpression of Cav3-F97C in adult rat cardiomyocytes caused a significant increase in late INa compared to Cav3-WT, and prolonged the action potential duration (APD90) in a nNOS-dependent manner.
It is generally known that the culture time is prolonged; the growth potential as well as cellulase biosynthesis of actinomycetes and bacterial strains was reduced, because culture medium becomes unfavorable with reduced nutrient sources and accumulated exchanging compounds, therefore, affecting cellulolytic activity of the isolates.
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