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The emergence of antibiotic resistance is inevitable, but we must seek to decrease its impact and prolong the effectiveness of the agents available to us.
Additionally, to prevent the emergence of the resistant strains and prolong the effectiveness of currently available antimicrobials, empiric therapy using agents such as vancomycin should not be prescribed for immuno-competent patients with mild skin and soft-tissue infections [ 44].
In 1998, the Institute of Medicine issued a workshop report that addressed the growing problem of antimicrobial drug resistance and potential strategies to prolong the effectiveness of existing drugs (17).
A global multidisciplinary effort to combat resistance that includes antimicrobial stewardship, infection control and prevention, and the development of new antimicrobial agents with activity against multidrug-resistant Gram-negative pathogens is critical to combat this public health threat and prolong the effectiveness of existing antibiotics.
Although metformin failure may occur more rapidly in clinical practice than in clinical trails, initiating it soon after diabetes diagnosis and while A1C is low might preserve β-cell function, prolong the effectiveness of metformin, reduce lifetime glycemic burden, and prevent diabetes complications.
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FRAC is an organization of major agrichemical company representatives, dedicated to prolonging the effectiveness of fungicides liable to encounter resistance problems and thereby limiting production losses associated with the poor disease control that results from fungicide resistance.
Numerical differences in populations of V. dahliae could mean that fungal antagonists are partially involved in delaying increase of V. dahliae and prolonging the effectiveness of the method.
The findings suggest that targeting 14-3-3ζ 14-3-3ζ 14-3-3ζ it regulates corld be a useful approach for enhancing and prolonging the effectiveness of endocrine theraproteins
Nonetheless, combined with the previous work on strategic use of drugs for reducing the likelihood of resistance emergence [ 19], our results suggest that prolonging the effectiveness of antiviral drugs would need to be considered in practical implementation of treatment strategies, especially with the expected delay in availability of a strain-specific vaccine.
These results suggest that polylysogeny, which is observed commonly among pathogenic bacteria (Figueroa-Bossi et al. 2001; Schuch and Fischetti 2009; Winstanley et al. 2009; Wang et al. 2010), may in itself be adaptive for the bacterial host as it hinders the process of immunization of competitor strains and prolongs the effectiveness of a lysogen's 'armory' of viruses.
In the era of increasing antibiotic resistance, prudent use of antibiotics is critical to prolong the clinical effectiveness of existing agents.
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