Transcripts were continuously distributed in the optic lobes, and this expression pattern suggests that the centaurin gamma homolog is related to developmental or proliferative steps in the optic lobe neurons.
One may speculate that the apparent proximal-to-distal netrin-1 gradient may function as a regulatory system that limits the lifespan of cells that undergo (i) multiple proliferative steps within the crypt and (ii) repeated mechanical and chemical insults originating from the intestinal lumen, two conditions that may increase the risk of cell damage and resultant aberrant behaviour.
Regarding WHI, we therefore postulated that for E+P, the P component, in a non-proliferative step, reactivates cancer stem cells in pre-existing but undiagnosed, perhaps dormant, disease [ 15].
Endomitosis may maintain platelet output even when earlier proliferative differentiation steps are impaired, thus providing a possible iron‐saving strategy.
Furthermore, Vav1 is also important in the T cell compartment for the assembly of optimal signaling responses directly or indirectly related to cell growth, such as specific T cell developmental transitions, thymocyte selection steps, and proliferative responses to antigens in the case of mature T lymphocytes [25].
Both epidemiologic and experimental studies suggest that non-atypical and atypical proliferative changes represent successive steps preceding the development of in situ cancer and then invasive carcinoma of the breast [ 4].
Megakaryopoiesis may be augmented at each differentiation step, including the proliferative phase, the endomitotic process, cytoplasmic maturation of MEGs and platelet shedding into the circulation.
The activity of hTERT is a rate limiting step in the proliferative capacity of advanced cancers and represents a prototypical and universal cancer antigen and marker.
Epidermal differentiation proceeds through successive steps that lead proliferative keratinocytes, positive for cytokeratins K5 and K14, to undergo terminal differentiation with the appearance of specific markers like K1, K10 and involucrin.
The MUTZ-3 population also contains three subpopulations of CD14+, CD34+ and double negative cells, previously reported to be transitional differentiation steps from a proliferative CD34+ progenitor into a non-proliferative CD14+ DC precursor [ 8].
