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Besides assessing the regenerative and proliferative potentials of SCs, we also investigated functional cellular markers attributable to mitochondrial function.
To gain a better understanding of the molecular basis of the different proliferative potentials of CTLs, we conducted genome-wide gene expression profiling of the CTLs after stimulation with tumor cells or CD3 mAb, respectively.
In conclusion, we demonstrated that LC-CD133+ display a higher Oct-4 expression with the ability to self-renew and may represent a reservoir with unlimited proliferative potentials for generating lung cancer cells.
Subpopulations of pulmonary arterial myocytes with differing proliferative potentials in response to injury are distinguishable early in life [ 42].
As documented in other studies (Rhodes, 1998), some GBMs could have very low proliferative potentials, and presumably grow predominantly by infiltration.
When we subclassified the grade of plating efficiency, normal HSCs obtained from adult BM showed variable degrees of proliferative potentials with grade 1 to grade 4, however, almost all of HSCs obtained from CB had high proliferative properties with grade 4. Notably, ASCs showed remarkably low proliferative potentials.
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Cellular senescence is a physiological phenomenon by which normal cells irreversibly lose their proliferative potential.
The xCELLigence RTCA System was then performed to monitor the proliferative potential of those cells.
Alterations in positions 9 and 10 neutralized the proliferative potential of pCDR3, whereas alterations in positions 6 8 and 11 15 retained the proliferative potential of the peptides.
Identification of the committed cardiomyoblast that retains proliferative potential may inform cardiac regenerative therapeutics.
"Skin stem cells have enormous proliferative potential," says cell biologist Elaine Fuchs of the University of Chicago.
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