Sentence examples for proliferative competence from inspiring English sources

We would expect (although we did not test this) that enhancing proliferative competence of SIRT1-deficient cells by reintroducing wild-type SIRT1 would have the additional effect of reinstating replicative senescence.

We found that preservation of proliferative (competence) was the most sensitive marker of mTOR inhibition, easily detectable even at concentrations of rapamycin when inhibition of mTOR was marginal.

These animals display a robust proliferative competence of cardiomyocytes in adult life, which provides a source to form a new myocardium after injury.

Preservation of proliferative potential (competence) correlated with inhibition of S6 phosphorylation by rapamycin.

Preservation of proliferative potential (competence) was measured by an increase in live cell number, when p21 was switched off.

While 1 μM U0126 inhibited neither phosphorylation of ERK nor IGF-1-stimulated proliferation, it did clearly attenuate tamoxifen agonistic behavior (P < 0.01), with a subsequent competence in proliferative inhibition at 10 μM.

It seems likely that T cells expressing low levels of TCRζ define polyclonal populations of antigen-experienced T cells in vivo based on their cell surface phenotype, tetramer staining, cytokine expression, proliferative responses, and migratory competence.

Thus, the T-cell pool in RA patients is under high turnover, eventually jeopardizing the proliferative reserve needed for immune competence.

In this study we have analysed the expression patterns of several cell cycle regulatory proteins and proliferation markers across the spectrum of vulval dysplasia, from normal squamous epithelium to VIN 3. The expression of all cell cycle markers and in situ DNA replication competence was restricted to the proliferative compartment of the basal layer of normal vulval squamous epithelium.

To clearly distinguish the potential to proliferate (competence) and actual proliferation, we introduce terms competence and incompetence (permanent loss of proliferative potential associated with cellular senescence).

"You lack management competence.