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By playing as barriers toward cellular migration, the additional coral particles would decrease the proliferation value.
On the other hand, by playing as substrates for cell growth, further microparticles led to the enhancement of proliferation value.
But at further time points, when the cells completely migrate throughout the scaffolds, this is the probability for the cells in bridging over the nanofibrous layers which effect the proliferation value.
According to the results, by the use of microparticles with 200 μm average diameter (Roll B and Roll E), the best situation for cell migration and growth was provided and subsequently, proliferation value is significantly higher than when microparticles with 100 μm diameter was used (Roll A and Roll D).
Ki 67 proliferation value is a major, but not the sole determinant of Oncotype Dx score.
Summarizing, these results suggested a critical CSC symmetric proliferation value at which tumor stabilization occurs.
Similar(47)
Increase in coral particle size led to the higher proliferation values at early time points.
Increase in coral percentage has dual effect on the cell proliferation values of prepared scaffolds.
Additionally, another ES cell line quite independent of IGF1 showed higher IC50 proliferation values, showing that CPMZ and MCD toxicity is actually related to IGF1R endocytosis inhibition and not due to non-specific secondary effects of these drugs (Figure S5).
To verify this putative dilution effect, proliferation values based on the initial 200 cells were compared with the proliferation values of the latter 800 cells.
Nuclear translocation and cell proliferation values were calculated as indicated under materials and methods.
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