Exact(3)
Previous studies with the Daphnia-Pasteuria system were not able to disentangle the activation, attachment and proliferation steps.
Environmental and host clone effects have been shown for the encounter and the proliferation steps [ 4, 30, 32- 35].
For example, evolutionary models studying the coevolution of the infectivity and the virulence steps [ 42] can fit our system in relation to the coevolution of the attachment and the proliferation steps.
Similar(57)
It has been proposed that nevi cells suffer an initial proliferation step, and are growth arrested by an oncogene-induced senescence mechanism [22].
The proliferation step (calculation of the probability and division of cells) is carried out once every 5 MCS.
It has been divided into three distinct phases: the initiation, the promotion or the proliferation step, and the termination.
However, resolving the infection process will allow the study of the immune response during the proliferation step without the confounding effect of genetic variation in the attachment step.
Excluding these steps, we suggest that the proliferation step is the one responsible for the reported sensitivity of the overall infection process for environment effects [ 32, 34].
The assay we developed makes it possible to test for susceptibility without the potentially confounding effect of the within-host proliferation step in the infection trials.
On the other hand, expression of virulence may depend on the host's immune response during the within-host proliferation step.
The activation and the attachment steps seem independent of the host's immune system (defined as a system that is potentially able to kill parasites), while the proliferation step is likely to be governed by the host's immune system.
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