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-- As you are aware, we have discussed the proliferation related activities of XXXXXXXXXXXX with the Chinese Government on a number of occasions.
Artemisinin and its derivatives can arrest cell cycle in the tumor cells, mainly by interfering cell cycle kinetics or blocking the proliferation related signaling pathway [16].
The relationship between enrichment of these gene sets and proliferation related differential expression is, in general, monotone, as depicted in Figure 4.
Moreover, this Erk centralized network also shows some proliferation related transcripts that were down-regulated by RA such as: MAPK6, INHBA, CSPG4, TGB1, CAV1, YWHAE, and CDC2.
These are well known for cell proliferation related to cell cycle progression and antiapoptosis.
These differences are reflected in immune functions and cell proliferation related functions.
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There is also evidence that cell proliferation-related genes have a high predictive power within these signatures.
Our study also showed that STAT3 inhibitor treatment down-regulated cell proliferation-related gene expression.
Consistent with our proliferation assay, many cell proliferation-related genes were significantly up-regulated upon lithium treatment (Additional file 1).
It has been found that estrogen can regulate the transcription of many cell proliferation-related genes [ 6- 8].
Pathways changed included stress-response, actin organization, ras-related, g-protein, calcium balance, and proliferation-related pathways.
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