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A precise measurement of tumor cell proliferation, provided by the expression of proliferation signature genes, identified patient subsets that differed by more than 5 years in median survival.
Therefore, neither accelerated differentiation, increased apoptosis, or decreased proliferation, provided an explanation for thyroid hypoplasia.
Our results suggest that a previously unrecognized effect of PTEN loss is to reduce the potential restraint on cell growth and proliferation provided by activation of AMPK.
Despite its name, the large T protein does not transform the stromal cells, but it does unlock their indefinite proliferation, provided that telomeric erosion is prevented by the telomerase activity present in the cells.
The lack of cell proliferation provided solid evidence that the observed reprogramming did not go through de-differentiation and reversion to a stem or progenitor cell phenotype, which are usually associated with proliferation.
Here, we attempted to identify additional targets of BRAF mutation-specific DNA methylation that could provide a favorable context, either to obtain a BRAF mutation or to attain the full potential of RAS-RAF-MEK-induced proliferation provided by this activating mutation.
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Glycolysis is presented as the "selfish" pathway used for cellular proliferation, providing both the metabolic precursors and the energy required for biosynthetic purposes, in the context of a plethora of substrates.
This connection between BAD expression and proliferation provides a possible explanation for an increase in expression of phosphorylated BAD protein in prostate tumors.
Interestingly, a recent model has been proposed in which surges of progesterone occurring during the reproductive cycle and pregnancy prompt mammary stem cells (MaSCs) proliferation, providing a window during which MaSCs (ER−/PR−) are targets for oncogenic mutations [25].
In the commonly used wound healing model (i.e., epithelial debridement at central cornea), the healing process is divided into three sequential and partially overlapping steps: cell migration reduces and eventually covers the wound surface, cell proliferation provides cells to rebuild the tissue and tissue remodeling to restore the stratified epithelium [9], [11] [16].
Reduction of ccp1 level by RNAi dramatically reduced SK-N-SH cell providingtion, providing further evidence that ccp1 can induce cell proliferation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com