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At present, the median values of the proliferation parameter are usually selected as cut-off points to identify risk groups.
The proliferation parameter represents the maximum proliferation that should be observed when the mutation level approaches 100%.
The histological grading system is constructed from a parameter of differentiation (glandular formation), nuclear appearance and a clear proliferation parameter (mitotic count).
Our modelling equation predicts that the wild-type mtDNA copy number (w) is a function of the mutation level (m) within a cell, and the mtDNA proliferation parameter : The proliferation parameter was determined from the wild-type and mutant copy number data by a non-linear least squares fitting routine using the Levenberg Marquardt algorithm in Origin 7™ (Northampton, MA).
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A sensitivity analysis also identified these two parameters, together with the proliferation parameters of the encapsulated cells, as the governing parameters for the occurrence of anoxia.
We measured the cell density at regular time intervals without breaking the configuration of the chamber, and analyzed the proliferation parameters by fitting the data to a logistic equation.
The reason was due to the fact that the discriminative power for both heterogeneity in HSC proliferation parameters and the BDT can be expected to lie in the chase phase of the data only.
Accordingly the predictive power of pretreatment proliferation parameters was tested.
No differences in cell proliferation parameters were found between initial and relapsed AML.
When these images were combined, vasculature, perfusion and proliferation parameters were analysed.
All these data have been correlated with those obtained from cell proliferation parameters.
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