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Splenomegaly often reflects an expansion of cellular proliferation outside of the bone marrow compartment, and is called extramedullary hematopoiesis (EMH).
Perhaps this is why RAC1 deletion and ROS inhibition do not affect normal LGR5 ISC function, i.e., these factors are critical for unrestrained proliferation outside the conventional niche.
In particular, the paper towel limits nematode survival and proliferation outside of the slug, thus minimizing the likelihood of repeated C. elegans-uptake by the slugs.
We have tested the hypothesis that inulin-type fructans (ITF), by promoting microbial production of short-chain fatty acids (SCFA), influence cancer cell proliferation outside the gut.
Given that LGR5 ISCs maintain high levels of ROS but are not dependent on it, we would hypothesize that increased RAC1-ROS is critical for proliferation outside the normal niche.
To represent quiescent ECs in the main vessel, we only allow for proliferation outside the parent vessel, at a minimum distance of one cell length from the vessel wall.
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CEDAR RAPIDS, Iowa - A day after Newt Gingrich forcefully denounced the proliferation of outside money into the Republican presidential race, one of his longtime aides announced that he was joining a group to help Mr. Gingrich win the party's nomination.
"Skyrocketing campaign costs and relatively low contribution limits compel candidates and elected officials to hold more and more fundraisers, and with the proliferation of outside political groups like super PACs, there is even more competition for donors' attention," said Brendan J. Doherty, a political scientist at the U.S. Naval Academy who has written about campaign fundraising.
The secretion of carbon compounds derived from cortical and epidermal cells stimulates the proliferation of fungi outside, on the surface, and inside the roots [ 134].
It is important to note that our manuscript is the first direct evidence of T cell proliferation occurring outside of the white pulp.
In order to determine if sex differences or hormonal modulation of cell proliferation persisted outside of the early neonatal period we quantified the number of Ki-67 expressing cells in the hippocampus of 3-week-old animals and found males and neonatally oestradiol-treated females had more Ki-67+ cells than control females.
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