Exact(1)
While there are exceptions, in the past few years we have been struck by the gap between the proliferation of function prediction methods and the rate of discovery of gene function, particularly for genes which are not already well characterized, despite the enormous increase in the amount of available data.
Similar(58)
The proliferation of functioning morgues has further compounded this problem.
To further explore the role of miR-1269 in promoting HCC cell proliferation, loss of function approach using a miR-1269 inhibitor were performed.
However, unlike GCK-1, both of these kinases act to limit cell proliferation, and loss-of-function mutants display gross tissue overgrowth [19], [56].
The mechanism of anti-rheumatic activity by HDAi has been ascribed to the suppression of proliferation and function of synovial fibroblasts.
Nevertheless, the levels necessary to induce suppression of proliferation and function of T cells in culture, were much higher than those produced by T cells.
This was accompanied by a decreased ability to induce T cell proliferation, suggesting relevance of function [ 28].
Furthermore, comparison of proliferation and function of ex vivo αCD3/IL-2-expanded CD44loCD62L+, αCD3/IL-2-expanded TEff CD44+CD62Llo cells, and unstimulated pmel splenocytes showed that αCD3/IL-2 expanded CD44loCD62L+ and TEff CD44+CD62Llo pmel cells proliferated (>5×) and showed comparable functionality (IFN-γ+TNFα+) whereas unstimulated pmel splenocytes did not (Supporting Information Fig. 3).
At the immunological level a subtle phenotype is observed due to the effects and fine-tuning of the signaling network at different levels of differentiation, proliferation and function of lymphocytes.
At the immunological level a subtle phenotype is observed due to the effect and fine-tuning of the signaling network at the different levels of differentiation, proliferation and function of lymphocytes.
In fact, some of the anti-MM effects of lenalidomide and pomalidomide may be due to their ability to overcome this immunosuppression in MM by their inhibition of the proliferation and function of Tregs.
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