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These data strongly indicate that necrotic lesions are repaired by proliferation of existing mature cardiomyocytes.
IL-2 is particularly active on CD4+ T cells, both in enhancing proliferation of existing T cells and in temporarily boosting neothymopoiesis [9].
Although we cannot exclude the possibility that EGF is causing proliferation of existing ductal cells within the culture, this data suggests that at least some of the ductal cells may arise directly from exocrine cells but not from hepatocytes.
In these contexts apart from proliferation of existing beta cells, differentiation of precursor cells located in ductal epithelium participate to the recovery of the beta cell mass [9], [23], [27] [33].
Potential alternative approaches for obtaining more insulin producing cells for the treatment of diabetes include proliferation of existing β-cells, differentiation from adult endocrine progenitor cells or embryonic stem cells, and reprogramming of non-β-cells such as acinar or liver cells to β-cells [18].
With thymic activity declining, T cells are maintained by homeostatic proliferation of existing T cells, which means that their diversity cannot be increased.
Similar(44)
Previously, it had been demonstrated that sympathetic denervation of WAT triggers an increase in fat cell number, which might be due to preadipocyte proliferation or maturation of existing preadipocytes [17].
On the other hand, it has been postulated that sympathetic nerves are involved in the control of lipolysis [15], [16] and it has been shown that sympathetic denervation of WAT triggers an increase in fat cell number although it is unknown whether this is due to preadipocyte proliferation or maturation of existing preadipocytes [17].
Sex steroids may have the potential to stimulate the proliferation and differentiation of existing NSC.
β-catenin depleted infarcted hearts showed increased numbers of cTnT-positive CMs in subepicardial and subendocardial positions, which the authors proposed not to be due to increased survival, proliferation, or hypertrophy of existing differentiated CMs.
This approach might overcome the limitations on cell expansion and proliferation of currently existing techniques.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com