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Using 25 mg TMZ per kg body weight for three single daily injections was found to reduce proliferation (number of BrdU-positive cells) in the dentate gyrus by more than 80% (277±23 vs. 1589±134 cells in vehicle controls, t-test: t 9) = 3.14, p<0.05).
Cell proliferation, number of stem cells, and sphere forming assays were performed 48 h after the last fraction of radiation.
Importantly, NAC treatment had no effect on proliferation, number of LGR5-GFP cells, or gross villus histology in WT mice (4 day and 8 week time points).
The results suggested that the addition of EGF or HB-EGF to PCMO differentiation medium superactivates MEK/ERK signaling which then increases both PCMO proliferation, number, and functional differentiation of PCMO-derived NeoHepatocytes.
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For that we analyzed cell proliferation, numbers of neural stem and progenitor cells, as well as cell survival and differentiation, in 12 month-old S7ΔEx1- and wildtype mice.
After mononuclear cell explantation, myogenic purity, viability, proliferation index, number of colonies, myogenic colonies, growth speed, maximum number of population doublings and fusion index were not different between RA and OA patients.
Ki67 staining was quantified with a proliferation index (number of Ki67 positive proliferating tumour cells per 100 tumour cells) using 200 counted cells per tissue core.
Effects of DBP on germ cell proliferation and number in human fetal testis xenografts and on germ cell number in fetal rat testes.
In electron microscopy analysis, apart from some pathological signs (aberrant Schwann cell proliferation, increased number of macrophages) observed on DMSXL thin nerve sections, a severe and significant loss (41%; P<0.01) in the number of unmyelinated axons was found (Fig. 5).
In a world of media proliferation, the number of Sunday papers changes little.
The TOR pathway is central to regulating cell growth (cell size or mass) and proliferation (cell number), and responding to stress such as nutrient starvation (glucose or amino acids) that ultimately affects cellular energy levels [13, 14, 28, 29].
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