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The second phase of proliferation is restricted to the wounds (also known as local proliferation), which is equivalent to the proliferation of adult stem cells for tissue/organ regeneration in mammals.
Upon amputation, neoblasts display two waves of proliferating response: one commencing 6 8 h following wounding, whereby proliferation increases throughout the body, followed by another occurred 40 h later, in which proliferation is restricted to the wounds (Wenemoser and Reddien, 2010).
Other modes of elongation are theoretically possible – for example one where cell proliferation is restricted to a subset of the transcription zone.
Cell proliferation is restricted near the bottom of crypts (in mammals) or in the inter-villus pocket region (in cryptless zebrafish), whereas apoptosis is restricted at the tips of villi.
The human oesophagus is a multistratified squamous epithelium, in which cell proliferation is restricted to the basal and the first few suprabasal layers.
Furthermore, these gene expression changes demonstrate that cell proliferation is restricted to a narrow window of time between 8 and 24 hr by the coordinated regulation of chromosome replication and cell division genes.
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Results showed that cell proliferation was restricted in the lower part of villi (Figure 1A, left panel).
Although this result was predicted, the extent to which proliferation was restricted to a subset of CD4+ or CD8+ T cells expressing high levels of TCRζ was unexpected.
We focused on two different modes of axial elongation — elongation via a localized source of cells, where all cell proliferations are restricted to a localized zone at one end of the tissue where active transcription of the morphogen producing gene occurs, and elongation via cell divisions distributed throughout the tissue.
The high proliferation rate is restricted to B220+DN T cells found in the gut epithelium whereas the high apoptosis rate occurred both in the gut epithelium and periphery.
The high proliferation rate is restricted to DN T cells found in the gut epithelium whereas the high apoptosis rate occurred both in the gut epithelium and periphery.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com