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We comment on the current poor understanding of the cellular and molecular regulation of endothelial cell proliferation in the context of a functional artery, and on the pitfalls of extrapolating from the well-studied process of neovascularization by sprouting vessel formation.
It may act in part to regulate proliferation in the context of such a negative feedback loop.
Specifically, downregulation of this miRNA seems to decrease proliferation in the context of hepatic stellate cell activation, an early event in liver fibrosis [81].
We used RCS chondrocytes to evaluate the effect of FGFR3 mutants on cell proliferation in the context of STAT1 and ERK activation.
Both in vitro and in vivo, its effect on cell proliferation was mediated through the activation of ERK1/2 as evidenced by the abolition of duct cell proliferation in the context of MEK/ERK inactivation.
Collectively, the genes discussed above define a molecular signature associated with the steady-state quiescent status of HSC, and suggest common targets whose perturbation can lead to enhanced cell proliferation in the context of either differentiation, stem cell expansion, or transformation.
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The finding suggests that sequence capture methods may be applied to mixed lymphoid populations, including oligoclonal proliferations in the context of disease or polyclonal populations at various stages of lymphoid development.
"We believe that the constant stepping up of sanctions has long since transcended the boundaries of solving non proliferation tasks in the context of the Iranian nuclear programme," the statement said.
These discrepancies highlight the importance of studying aerobic glycolysis in intact animal models, in which growth and cell proliferation occur in the context of normal physiology.
We combined EdU labeling with intravascular staining during day 5 CPS-vaccination to localize where CD8+ T cell proliferation occurs in the context of the sequence of their differentiation.
We previously demonstrated that estrogen-induced endometrial proliferation is enhanced in the context of hyperinsulinemia and insulin resistance.
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