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Consequently, hydrocephalus caused by meningothelial proliferation impeding CSF flow was more frequent in adCre Nf2flox2/flox ;Ink4a*/* mice (Table 1).
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While iPS cells resolve the bioethical concerns surrounding the use of stem cells extracted from human embryos, the production of teratomas as a consequence of uncontrolled cell proliferation impede the translational application of these cells for stem cell therapy [10, 11].
In addition, proliferation was impeded, comparable to control cells which are not expected to proliferate in the absence of TPA (see Figure 5e: 'ctrl' and 'N-RAS61K').
The growth of FLSs maintained at low density is faster than in high density cultures because proliferation is impeded by contact inhibition.
High-grade gliomas are typically heterogeneous and the delineation of areas of high and low proliferation is impeded by partial volume effects and blurred borders.
Likewise, miR-200c and miR-141 directly inhibited JAGGED1, impeding proliferation of human metastatic prostate cancer cells.
As Phb2 deficiency leads to a reduced cellular proliferation rate impeding the generation of conventional stable cell lines (Merkwirth et al, 2008), we utilized a doxycycline-inducible promoter to express short hairpin RNAs directed against Phb2 mRNA in mouse podocytes (Shankland et al, 2007).
Microtubule proliferation reduces contraction by impeding sarcomeric motion; modulation of sarcoplasmic reticulum Ca2+ release may also be involved in this effect.
Thus, while the model results demonstrated that sequestration of IGF1 by IGFBPs or by an IGF1-neutralizing antibody inhibits cell proliferation, an antibody which blocks IGF1R is predicted to be the more effective tool for impeding IGF1-mediated cell proliferation.
These cytoskeletal proteins have been shown to impede proliferation when ectopically expressed [4], [5], [6].
Blastula stage cell proliferation is also impeded by knockdown of either wnt8 or cyclinD.
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