Meanwhile, the danger of proliferation has heightened further because of access to the technology and the emergence of non-state threats.
Concerning Iran, whose nuclear program is a major worry for Saudi Arabia and the other Persian Gulf nations, Mr. Kerry repeated the American refrain that time was running out for a diplomatic solution, and that allowing Iran to develop nuclear weapons would encourage nuclear proliferation and heighten tensions in the region.
These pathways were modulated by A20 in a manner that favored decreased inflammation, heightened proliferation, and optimized metabolic control and energy production.
The reduced capacity for epithelial cells to undergo apoptosis in the gastric corpus and heightened proliferation-to-apoptosis ratio in gastric epithelial cells may therefore result in cells that have an increased susceptibility to neoplastic progression following DNA damage.
Finally, increased monocyte/macrophage accumulation within atherosclerotic plaques is related with heightened macrophage proliferation and augmented frequencies of apoptosis.
However, this relationship does not necessarily diminish the significance of TIMELESS in cancer simply because heightened cellular proliferation can be an important driver of the cancerous state.
Interestingly, recent immunohistochemical and magnetic resonance imaging studies have found that heightened vascular proliferation occurs in basal-like breast cancers [ 21, 22].
Consistent with heightened KC proliferation, KC-assigned PP-increased DEGs were frequently associated with organelle fission, cell division and the cell cycle (data not shown).
The reduced export of CD4+ SP thymocytes from BALB/c c-FLIPL Tg mice to the periphery may result in heightened homeostatic proliferation in the periphery as shown by increased BrdU incorporation in splenic CD4+ T cells in these mice.
This heightened anti-proliferation response suggests that cells with reduced 19S subunits are primed to enter a protected, quiescent-like state when flux through the proteasome is reduced.
Indeed, heightened lesional macrophage proliferation has been proposed to drive murine atherosclerotic plaque progression.
