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The proliferation group of genes appeared to be the dominant feature in clustering the samples most notably into 2 sub-clusters of branch C. Figure 3b shows 2-way hierarchical clustering of just the AI-resistant samples.
Because children are known to be more susceptible than adults to risks of cancer from radiation, Physicians for Social Responsibility, a U.S. antinuclear proliferation group, condemned the exposure limit as "unconscionable".
Almost all kinase genes of the "proliferation" group (Figure 3) associated with DNA repair, cell cycle control, mitotic chromosome handling, chromatin handling and regulation of cell growth.
Thirty of these genes clustered in three groups: an estrogen receptor group, a proliferation group and an immune group.
A comparison with the proliferation group in Oncotype DX suggests that AP4 contains significantly more prognostic power than that group.
Furthermore, when dividing the tumours into a high and a low proliferation group based on expression of the proliferation marker Ki67 and mitotic index, miR-378a-5p was more highly expressed in tumours of the high proliferation group compared with tumours in the low proliferation group (P<0.001, Figure 5D).
Similar(40)
Proliferation groups were created by dividing the samples in two groups.
Securin and MAI, in turn, allocated 64% of cases into different proliferation groups.
In the carcinoma and proliferation groups, similar median values of PSV, 34.10 and 34.20 cm/s, were obtained.
Results from Runx2 staining at day 14 and 28 are shown for the proliferation groups in Figure 6.
Patients were dichotomised by the basal Ki67 expression (percentage of tumour nuclear area positive for Ki67) to define low and high proliferation groups.
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