Following the promising improvement in proliferation-free survival reported in the ECOG-E2100 study, bevacizumab, a monoclonal antibody against vascular VEGF-A, was approved for the first-line treatment of MBC in 2008 [ 58].
That the recording industry has been reeling from the one-two punch of poor economic conditions and the proliferation of free Internet downloading is old news.
But a proliferation of free or low-cost games on the Web and for phones limits how much the major game publishers can raise prices.
The migration of advertising on to the internet and the proliferation of free information may be killing the newspaper; many local papers in both Britain and America have shut down.
A proliferation of free Wi-Fi hot spots — like LinkNYC, the network of mini-towers that will soon provide one-gigabit-per-second Internet access across New York City — will further the sense of "ambient intimacy" that such connectivity engenders.
The proliferation of free online courses from top universities like Harvard and Stanford over the past year has prompted great interest in online learning.
It would be fair to say that it is worth hundreds of millions of pounds to someone, but also that because of the proliferation of free sites, that wealth is being concentrated in fewer and fewer hands.
With the proliferation of free Internet pornography, his insistence on engrossing story lines, high-quality visuals, naturalistic sex scenes and pubic hair was more than a matter of personal preference: it was a matter of survival.
There is now more standup available online than anyone could possibly consume, and while some of it's excellent, devout comedy fans will know that, when the last comedy boom died in the early 90s, many blamed the proliferation of free standup on television for diluting the product and discouraging people from going out to live shows.
The proliferation of "free" media on the Internet seems to have convinced an entire generation that the old hacker slogan from a quarter-century ago, "information wants to be free," can be an organizing principle for the information economy of the future.
