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It was demonstrated that crude aqueous extracts of P. indica root effectively inhibited cancer cell proliferation, focus formation, and migration at low concentrations (100 300 μg/ml).
NIH/3T3 cells stably expressing this mutant showed significantly increased cell proliferation, focus formation, and anchorage-independent growth in soft agar, which typically correlates with the tumorigenic potential in vivo.
This is the first study to demonstrate the in vitro anti-cancer property of P. indica aqueous extracts in the inhibition of cancer cell proliferation, focus formation, and migration.
The results showed that HBx3′-40 at C-terminal mutant promoted cellular proliferation, focus formation, tumorigenicity, invasive growth and metastasis by promoting the cell cycle progression from G0/G1 to S phase; in contrast, HBx3′-30 at C-terminal mutant repressed cell proliferation by arresting cells in G1 phase (22).
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This work aim to analyze the effect of different architectures of 3D tubular scaffolds with empty core on fibroblast proliferation, focusing the tissue engineering application.
AML12 immortalized hepatocytes were used to study propiconazole's effects on cell proliferation focusing on the dysregulation of cholesterol biosynthesis and resulting effects on Ras farnesylation and Erk1/2 activation as a primary pathway.
The knockdown and mutant (S10A) of histone H3 suppressed LMP1-induced CNE1 cell proliferation, foci formation and AP-1 activation.
As a result, this histone modification is associated with increased cell proliferation, foci formation, and AP1 activation in NPC [50].
In the rats which received nZnO treatment without prior DHPN treatment, alveolar cell proliferation foci, recognized as thickening of the alveolar wall with proliferative alveolar epithelium, were observed, but significant differences from the saline group were not observed.
Single cell necrosis of the tubule epithelium, with associated granular cast formation and papillary mineralization, is followed by sustained regenerative tubule cell proliferation, foci of tubule hyperplasia in the convoluted proximal tubules, and renal tubule tumors.
As expected for data derived from our previous study [6], the most represented functions in 48A9 cells were cell growth and proliferation (24 focus genes), cell morphology (13 focus genes), cell death (18 focus genes), and cancer (25 focus genes).
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