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Cho, B., Varada, R., Ge, Q., Eisen, H.E., Chen, J. Homeostasis-stimulated proliferation drives naïve T cells to differentiate directly into memory cells.
The resulting sustained proliferation drives the development of BCC and other follicle-derived tumours.
Importantly, pharmacological blockade of PPARγ and/or Rb inactivation inhibits CGNP proliferation, drives medulloblastoma cell death and extends survival of medulloblastoma-bearing animals in vivo.
During ageing there is also an associated decline in B cell development in the bone marrow, the most significant being at the transition of pro-B cells to pre-B cells, while in the periphery, homeostatic proliferation drives the expansion and accumulation of autoantibody secreting cells in the follicular compartment.
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In turn, I-8 inhibited cell proliferation driven by RET wildtype and gatekeeper mutation.
Our observations show that intestinal polyposis is initiated by PTEN-deficient ISCs that undergo excessive proliferation driven by Akt activation and nuclear localization of β-catenin.
We also suggest a simple way to evaluate whether cell motility or proliferation drive the process, based on a non-dimensional parameter.
Mutations in Hippo pathway components in Drosophila consistently result in an increase in cell proliferation driven by excess Yorkie in the nucleus (reviewed by Pan [44]).
The uncontrolled proliferation driven by latency III is also seen transiently in vivo.
This is likely due to inhibition of both angiogenesis and cell proliferation driven by the presence of a VEGF/VEGFR-2 autocrine loop in tumor cells.
Endometrial cancer growth at the invasive front is regulated by a higher rate of cellular proliferation, driven by the alteration in cell cycle regulation [40], [41].
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CEO of Professional Science Editing for Scientists @ prosciediting.com