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A combination of these two functions leads to loss of proliferation control, whereas each of these functions on its own cannot.
These data suggest that MK2 activity plays a substantial role in proliferation control in WS cells.
Immune system modulation is an emerging concept in cancer cell proliferation control.
These data suggest that total JNK1/2 activity does not play a substantial role in the proliferation control in WS cells.
The efficient production of recombinant proteins by Chinese Hamster Ovary (CHO) cells in modern bioprocesses is often augmented by the use of proliferation control strategies.
These so-called epimutations contribute to the loss of proliferation control in cancer cells [4], [5], [6].
It is also an important regulator in cell fate decisions, such as programmed cell death and proliferation control, and is critical in tumorigenesis.
Further, Zonula Occludens Protein 1 (ZO-1) is expressed on RPE cells and is involved in cell density and epithelial cell proliferation control [22], [23], [24].
Thus, one possible mechanism for cell proliferation control in the non-chamber myocardium by tbx2a and tbx3b is by regulation of expression of cell cycle genes.
Gain- and loss-of-function studies have suggested various functions for Notch including proliferation control, differentiation switch of developing epidermis and formation of hair follicles [12] [17].
How signaling pathways coupled to nutrient uptake and expenditure couple to the cell cycle machinery and proliferation control has been an area of increasing investigation.
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