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Versican also has a regulatory effect on cell proliferation, being highly expressed in proliferating dermal fibroblasts (Zimmermann et al. 1994), as well as muscle cell proliferation during development (Velleman et al. 2012).
A significant inflammatory component may underlie this fulminant fibroglial proliferation, being possibly amenable to modulation by aggressive anti-inflammatory therapy delivered concurrently with parenteral antibiotics.
Taken together, relatively large scale, unbiased transcriptome analyses of NSC/NPC single cells, cultured cell mixture, as well as brain tissues surrounding the neurogenic zone, all demonstrated reduction of cell proliferation being associated with aged NSC/NPCs.
We anticipated a significant association between Ki-67 and [18F]FLT uptake given that [18F]FLT is a marker of proliferation, being a substrate for the cell cycle regulated enzyme TK-1, an enzyme which is up-regulated in proliferating cells.
A recent preoperative study of letrozole with or without the mammalian target of rapamycin (mTOR) inhibitor everolimus reported greater tumor shrinkage for the combination, with changes in proliferation being predictive for response together with strong expression of protein S6 kinase, a downstream marker of activated mTOR.
In vitro studies demonstrated that ZOL was more potent against the OSRGA cell line than osteoblasts (with a half-maximal inhibitory effect on proliferation seen at 0.2 and 20 μM, respectively), the ZOL-induced inhibition of OSRGA proliferation being due to cell cycle arrest in S-phase.
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Proliferation is always dangerous.
"Nuclear proliferation is another".
The risk of nuclear proliferation is growing.
Safety and weapon proliferation were non-issues.
The risks of proliferation are growing.
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