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The potentially reduced JNK signaling may lead to G1 cell cycle arrest in TDI chondrocytes, as FOXM1 (−3.1 fold change) is known to promote proliferation and control the G1/S transitions by acting through MAPK8 (−2 fold change) [50].
The Student's t-test was used to analyze the differences between the values of Chinese herbal-enhanced cell proliferation and control cell proliferation in each group.
The genomic mechanism is significantly involved in cell proliferation and control of cell phases, confirming a significant effect of estrogen on cell cycle regulation.
The identification of numerous genes involved in the mitotic checkpoint and cell proliferation indicate that the experimental procedure may be useful for understanding cell proliferation and control in vertebrates within the context of the whole animal physiology.
The identification of numerous genes involved in the mitotic checkpoint and cell proliferation indicates that, with a more detailed time course experiment, this procedure represents a good model for understanding cell proliferation and control within the constraints of whole animal physiology.
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GRH also positively regulates post-embryonic cell proliferation and controls expression of proliferating cell nuclear antigen (PCNA) gene, suggesting its involvement in DNA replication.
DDB2 functions as a tumor suppressor in normal cells, at least in part by regulating cell proliferation and controlling p53-mediated apoptosis.
Overexpression and activation of AKT1 produces estrogen and IGF-1 independent proliferandon and controls an antiapoptotic pathway.
Importantly, ERK 1/2 has been reported to play an essential role in cell proliferation and controlling adipogenesis [ 21].
We also found that treatment with miR-29b diminished NSC self-renewal and proliferation, and controlled their fate, directing their differentiation along certain cell lineages.
Altogether, these data suggested that miR-143 negatively controls cell proliferation and positively controls cell death of prostate cancer cells.
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