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Results confirm that microstructures not only affect cell proliferation and alignment but also have a synergistic effect with osteogenic medium on rMSC differentiation into mature osteoblasts.
In this paper, we report an innovative approach to bioactivate planar surfaces with oriented collagen molecules to promote cells proliferation and alignment.
The results demonstrated that TEVGs under dynamic flow conditions had better outcome than static culture controls in terms of cell proliferation and alignment, ECM production and cell phenotype based on transcript and protein level assessments.
The process of angiogenesis is complex, and typically consists of proliferation and alignment to form tubular structures [41].
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Furthermore, we studied attachment, proliferation, differentiation and alignment of neonatal rat cardiac fibroblast cells (CFs) as well as protein expression, alignment, and contractile function of cardiomyocyte (CMs) on PGS gelatin scaffolds with variable amount of PGS.
The processes of angiogenesis include endothelial cell (EC) proliferation, migration, and alignment into tubular structures.
Here, the optimized electrospinning conditions for P VDF-TrFE) nanofibers were achieved and these nanofiber scaffolds (NFSs) were used for imP VDF-TrFEergy harvester inanofibers cell proliferation and cell alignment growereachievedions.
Finally, various classes of applications of nanotopographic patterning are discussed, including mechanisms for controlling cell adhesion and proliferation, alignment and differentiation, and functional tissue formation.
It is reported that mechanical stimulation plays an important role in the induction of cell proliferation and differentiation, cell alignment, extracellular matrix synthesis, and tissue remodeling [ 31, 32].
Several groups showed that the proliferation, migration, alignment and gene expression of cells were affected by the alignment and the dimension of nanofibers in contact with cells (Figure 2 (A-H)).
Angiogenesis induced by hypoxic tissue conditions or by angiogenic stimuli, is a complex biological process involving the directional migration, proliferation, intercellular alignment and adhesion of endothelial cells [3].
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