"There are some problematic links between the welfare state and personality, and the welfare state can proliferate employment resistance," he adds.
Some of these mediators such as IL-6 retain direct antiapoptotic as well as pro-angiogenic effects, conferring survival advantage to proliferating tumour cells and promoting resistance to cytotoxic therapies (Guo et al, 2012).
For instance, cancer cells develop the capacity to escape DNA damage caused by pharmacological doses of platinum-based therapy via reverse polyploidy (a.k.a 'neosis' [ 55- 57]), leading to the formation of diploid, rapidly proliferating cells with increased platinum resistance [ 58].
Strains able to develop resistance will proliferate while those unable to develop resistance are unable to survive or flourish.
BiP-mediated resistance is not limited to proliferating tumor cells.
The ability of stem-like cells to enter in a quiescent or slow-dividing state can also contribute for their resistance to conventional therapies that target proliferating cells.
"But if we allow resistance to proliferate, then we undermine all of those medical advances," she said.
Our study has important implications for understanding the spatiotemporal functions of BRCA2 in proliferating human cells and how patients with BRCA2 deficiencies develop malignancy and therapeutic resistance.
Furthermore, relapses due to drug resistance stop occurring, a reflection of the fact that the LSC population is not proliferating anymore but rather shrinking over time.
