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Furthermore, the α-PH3 immunolabelling method revealed other proliferating regions rather than a posterior proliferation zone in onychophoran embryos.
The association of CROC-4 expression with proliferating regions of developing brain and retention in regions of the adult brain, as well as the punctate nuclear location, suggest that CROC-4 participates in brain-specific c-fos signaling pathways involved in cellular remodeling of brain architecture.
Consistent with its broad function, SPT is expressed in proliferating regions of both vegetative and reproductive tissues, including the root [ 16, 24].
Histologically, five and two synovia showed mild and moderate synovial proliferation with or without some degree of inflammatory reaction, respectively, and could not be distinguished from OA. Tax-positive synoviocytes were observed sparsely in all samples, and often appeared frequently in actively proliferating regions.
The ability to diffuse through the tissues will augment therapeutic effects, and enable repression of blood vessels in the cancer cell proliferating regions.
From these observations we concluded that Dnmt2-EGFP is expressed in DNA-synthesizing tissues such as endo-replicating nurse and salivary gland cells as well as in the proliferating regions of the adult germ line.
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Taken together, these data suggest that a highly proliferating region corresponding to the germinative zone is formed in zebrafish lens.
The bystander response was observed when the actively proliferating region within an explant outgrowth was targeted and the distribution of additional micronucleated and apoptotic cells was nonuniform.
Thus, oncogene PIK3CA is significantly upregulated in non-proliferating regions in human ovarian cancer in vivo.
These non-proliferating regions always lack blood vessel support and contain numerous necrotic/apoptotic cells as well as rich lymphocyte infiltrating (Figure 3).
Similarly to the reciprocal expression observed in the human specimens, strong p110α expression was detected in tumor cells only in Ki67−, non-proliferating regions (Figure 1 F to H).
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