Sentence examples for proliferating potential of from inspiring English sources

How the maternally provided MEGs contribute to the health and proliferating potential of the PGCs will be an interesting area for future exploration.

The limited proliferating potential of in vitro cultured cells has been widely investigated in the context of cellular aging [ 4].

The CellTiter-Glo luminescent assay was performed to evaluate the proliferating potential of cells.

Replicative senescence (RS) that limits the proliferating potential of normal eukaryotic cells occurs either by a cell-division counting mechanism linked to telomere erosion or prematurely through induction by cell stressors such as oncogene hyper-activation.

At first glance replicative senescence (RS) seems to be constituted by two separate phenomena: on the one hand there is RS related to exhaustion of a certain proliferating potential of the cell, this has been linked to some sort of counting mechanism that determines the number of completed cell cycles before triggering replicative senescence [ 4].

Therefore, there is a progressive reduction in the proliferating potential of the hepatocytes as a function of age, and in older animals the percentage of residual hepatocytes able to re-enter the cell cycle after partial hepatectomy is significantly reduced [ 33].

However in healthy but older animals the fraction of remaining hepatocytes able to re-enter the cell cycle after liver injury is reduced to < 70%., This spontaneous loss of proliferating potential as a function of age has been linked to the terminal differentiation of the hepatocytes.

As K13-induced spindle cell transformation of HUVECs is accompanied by their loss of proliferating potential, it is not possible to generate stable cultures of long-term proliferating HUVECs expressing K13 for the purpose of global gene expression analysis.

Yet such interactions increase in strength and number as a function of time so that DNA loops become shorter on average and more homogeneous in size as a function of age and this correlates with the loss of proliferating potential.

However, single-cell cloning studies with normal human fibroblasts revealed a bimodal distribution in the replicative potential of clonally derived cells, indicating that there is a stochastic loss of cell proliferating potential [ 28- 30].

For addressing this question let us consider the fact that both RS and STASIS are non-reversible at least in human cells [ 3, 5] and yet RS can by bypassed in human tissues with proliferating potential by a number of mechanisms such as reactivation of telomerase, leading to cell immortalization as a precondition for tumorigenesis [ 5, 22].