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Dopaminergic projections arise from the VTA and then project diffusely across the frontal cortex [6], [7].
This finding concurs with a previous report on the distribution of STN-projecting neurons (Kita and Kita 2011) and suggests that the PPN projects largely separately to these two motor structures but the projections arise from neurons that are intermingled in the same regions of the PPN.
The thalamic projections arise from subicular cells that lie deep to those that project to the mammillary bodies (Wright et al., 2010).
In this latter species, 60% (against 80% in rat; [13]) of MCH cortical projections arise from MCH/CART neurons.
Similarly in mouse, double labeled MCH/CART axons in sections through the spinal cord were very rare, suggesting that, as in rat, spinal projections arise mostly from MCH perikarya that do not express CART (not illustrated in mouse), (see 10 for the rat data).
Sparse residual projections arise from GPT neurons generated before ganciclovir treatment, whereas surviving and replacement GPT neurons retain the capacity to emit local infracortical axons.
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(a) Axial and (b) coronal T2-weighted images show a cystic mass with papillary projections arising from the medial wall (white arrows).
Behavioral studies have indicated that midbrain dopamine projections arising in the ventral tegmental area and substantia nigra play a central role in integrating violations of expectancy in reward-related paradigms.
They are variable in shape, often fusoid-ventricose (fuse-shaped with a swollen center) or with 2 3 needle-like projections arising from the apex; the projections are sometimes forked.
The tracings of coronal sections were then used to generate dorsal view reconstructions of the furthest distal points where labeled axons were found, as well as axon density plots of projections arising from injection sites.
In this system, projections arising from the midbrain dopamine (DA) system are thought to provide a learning signal that enables associative transfer of the reinforcer value to cues that reliably precede it [49].
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