The appropriate choice of monomeric unit patterns can lead to oligomers that recognize diverse interaction partners: cavities for small-molecule entrapment or the projection of functional groups from a well-defined scaffold to mimic complex structures such as protein surfaces.
In contrast, variation in the 3D projection of functional groups has not been exploited to modify binding properties.
These methods have been previously applied to detection of ortholog proteins, projection of functional pathways, and construction of phylogenetic trees.
Non-cholinergic neurons with descending projections were shown to have distinct electrophysiological properties to non-cholinergic neurons with ascending projections, supporting the notion of functional differences between these two pathways in normal animals (Ros et al. 2010).
In the literature of generative grammar, it has been widely assumed that utterance particles in Chinese are heads of functional projections in syntax, such as CP (Lee 1986, Cheng 1991, among many others), split CP in a cartographic periphery domain (Li 2006), or some functional phrases beyond CP (Tang 邓思颖 2010, Tang 2015).
Here, we show that the unique properties of the SNr microcircuit both intrinsic properties of projection neurons and the organization of functional activity combine to implement a potent feedback inhibitory circuit that can exert a divisive gain control effect on the basal ganglia output.
The anterior, but not posterior, part of the hippocampus projects to the PFC (Cavada et al. 2000), and these projections, as well as the strength of functional connectivity between MTL and PFC, increase with age (Menon et al. 2005).
We consider the problem of projection of genetic information into the functional space of the proteome, where the latter is defined as a set of molecular functions performed by proteins.
After computing the optimal projection of gene vectors into the functional label space based only on the training data, we calculated the affinity scores (see Equation 15) to get a ranked list of test genes for each function.
This strategy greatly facilitates not only the development of functional predictions for uncharacterized genes, but also accurate projection of this knowledge, once verified, to other species.
Finally, our results suggest that the hindbrain-forebrain noradrenergic projections in the zebrafish are of sufficient density to be of functional utility.
