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Within this broad theme, GO categories relating to the development of the nervous system (e.g. "regulation of nervous system development" (ALH vs. MI q = 1.99 × 10−4; LH vs. MI q = 5.36 × 10−2), "neuron projection guidance" (ULH vs. MI q = 1.17 × 10−2; ALH vs. ULH q = 1.40 × 10−3) and "nervous system development" (ALH vs. ULH q = 3.30 × 10−4)) ranked highly for all four comparisons.
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This long distance projection requires proper guidance for correct axonal pathfinding and target selection at each point from its origin to its destination, potentially through cell adhesion molecules (Faulkner et al. 2008; Runker et al. 2008).
With the patchy morphogen concentrations in place, the neurons can go on to connect (for example) to like patches by intralaminar axonal projections under active guidance of their growth cones.
This orthologue was predicted to interact with 11 distinct genes involved in axon guidance, neuron projection, embryonic and/or larval development (see Figure 2b; Additional file 7).
Axon guidance, cell projection organization, neuron development, axonal defasciculation, cell motion, cell recognition (20 genes) were also enriched in line with our previous results implicating the role of Manf in neuritogenesis [ 5].
A wide spectrum of biological processes were significantly enriched, including neuron differentiation, neuron projection morphogenesis and axon guidance, that are consistent with established roles for Foxa1/2 in mDA neurons (Fig. 1G; supplementary material Table S5).
For example, Coca-Cola is followed by at least 50 senior security analysts whose earnings projections, derived from management guidance, rarely deviates quarterly more than a penny a share.
Consequently, it would be beneficial to explore new projections for intraoperative fluoroscopic guidance of percutaneous screw insertion.
Perhaps, these decussating fibers are not corticospinal axons but pioneer fibers in the CST serving as scaffolds or temporary targets for the developing corticospinal axons, in the same way as the establishment of subcortical projections is dependent on the guidance of pioneer axons from SP cells projecting toward the internal capsule (McConnell et al. 1989, 1994; Kim et al. 1991).
That projection was below its earlier guidance of 38 cents to 42 cents a share.
To our knowledge no other study has investigated a role for NEUROD2 in fasciculation and guidance of cortical projection neuron axons.
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