Medical isotopes can also be produced in cyclotrons or spallation neutron sources, for example, but dedicated facilities were prohibitively expensive until the wide embrace of a technology called positron emission (PE) scanning in the 1980s.
Together, these three factors make extremely wide PSDs prohibitively long and expensive to simulate with modern computing technology.
Even offshore, new seismic 2D surveys over wide areas are prohibitively expensive, when considering the expanses involved.
Because of the logistic (or probit) link function, the Bayes factor can no longer be evaluated in a closed form; instead, the integration over a prior distribution of β requires a numerical method such as the Laplace approximation (cf. Guan and Stephens 2008), which can be prohibitively slow for a genome-wide analysis.
Fine-tiling arrays provide a higher resolution for detecting small deletions but are not in widespread use and are prohibitively expensive to implement for genome-wide data.
Although genome-wide sequencing is still prohibitively costly for large population studies, array approaches are being frequently used to delineate DNA methylation signatures of disease states in primary clinical material rather than cell lines.
Throughout the nineteen-nineties and early two-thousands, it was prohibitively difficult for an independent game maker to reach a wide audience.
Finding an exact solution to a partitioning task of this kind is believed to be an NP-complete problem, making it prohibitively difficult to solve for large-scale networks, but a wide variety of heuristic algorithms have been developed that give acceptably good solutions in many cases.
Some programs are commercial products that can be used for a wide range of study designs, but can be prohibitively expensive and may also require great knowledge in statistical theories and strong computer programming skills.
However, a rough estimate of the cost of implementing such a policy state-wide shows that it would most likely be prohibitively expensive.
