But some lightweight processes don't necessarily require a full GPU cluster, which running for a company — especially a smaller one — might become prohibitively expensive very quickly.
In contrast, in the current implementations of the two other similarity scores the algorithms require all pairwise RMSDs, the calculations of which may become prohibitively expensive for very large ensembles.
RCTs are not usually conducted at scale because they are very expensive, prohibitively difficult, and randomisation to intervention and control groups on a large scale is practically and politically difficult.
Although large placebo-controlled double-blind phase III trials can provide useful information in both regards, these are very expensive, prohibitively so if the disease is rare, and even very large studies may be insufficiently powered to detect population effects [ 1].
Journals are very expensive, often prohibitively so.
However, the computational cost of conventional numerical modeling methods, such as finite-difference method and finite-element method, becomes prohibitively expensive when applied to very large models.
Of course, in practice testing all topologies very quickly becomes prohibitively expensive with the growth of the number of nodes.
Molecular markers are highly suitable tools to assess the diversity within groups or the divergence between them, but their application might be prohibitively laborious and expensive for very large collections of minor crop species.
Using gDNA allelic ratio as an internal control for mRNA imbalance is a more robust design, but obtaining this gDNA control for high-throughput sequencing data is, currently, prohibitively expensive owing to the very large amount of high-throughput resequencing needed to obtain high read depth for gDNA using whole genomes.
That means the drugs must be very safe and not prohibitively expensive.
