Such simulations can be prohibitively slow.
In the analyses of large populations, comprehensive validation of newly observed SNVs is sometimes prohibitively expensive and tedious using these traditional low-throughput methods.
Even for known complexes, manual selection of ∼100 000 single-particle images is prohibitively time-consuming and tedious.
If we had to survey all of the medical expenditures of a hospital over all time points, it would be tedious, time-consuming, and prohibitively expensive using any of the currently available control charts.
There is no doubt that manual morphometry is prohibitively time consuming, difficult to perform correctly, tedious, predisposing to observer fatigue, and subject to many sources of error [ 3– 6].
While these mechanisms are conceptually straightforward to analyze, evaluating kinematically admissible velocities for a particular arrangement of blocks can be a tedious process, and optimizing the geometry of the mechanism is often prohibitively cumbersome for more than a few blocks.
Prohibitively high labour costs and abundant Iranian imports mean that only select locales continue the tedious harvest in Austria, Germany, and Switzerland among them the Swiss village of Mund, whose annual output is a few kilograms.
"So it's tedious, really tedious.
