Sentence examples for prohibitively large increase from inspiring English sources

Although internal ion formation can be used for diagnostic purposes in top down experiments with extensive a priori knowledge of the protein of interest, accommodating internal ions in a high throughput identification search strategy would cause a prohibitively large increase in fragment ion search space.

However, randomized trials are usually conducted comparing only two (or seldom three) options because inclusion of more treatment groups would require prohibitively large sample sizes and substantial increases in research costs and as a consequence, studies comparing all available treatment options at the same time are usually lacking.

Sample size requirements for a definitive prospective study on time loss injuries is prohibitively large, but using an MID of 50% increased risk, one could use the case-crossover design with prospectively collected control data to investigate the role of psychological states by following 210 artists for ~2-2.5 years for TL-1 injuries, and for ~3-5 months for medical attention injuries.

As the number of molecular species and their copy numbers increase, the state space will eventually become prohibitively large for explicit computation even with an optimal algorithm.

It seems likely that, during genome evolution, gene duplication (and death) rate also tends to 0 as duplications leading to increase in gene number become deleterious when the size of some paralogous families becomes prohibitively large.

3D field models become prohibitively large.

In fact, Serra's work is prohibitively large for many museums.

This routing overhead is likely to become prohibitively large as the network size grows.

Banishing the problem entirely would require prohibitively large and expensive versions of devices called filter capacitors.

However, these algorithms may need prohibitively large computational time and fail to produce accurate solutions.

The study of penetrator performance without free-surface effects can require prohibitively large monolithic targets.