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Despite the fact that fast computers are nowadays available at low cost, there are many situations where obtaining a reasonably low statistical uncertainty in a Monte Carlo (MC) simulation involves a prohibitively large amount of time.
Up till recent years, predicting wind loads on full-scale tall buildings using Large Eddy Simulation (LES) is still impractical due to a prohibitively large amount of meshes required, especially in the vicinity of the near-wall layers of the turbulent flow.
This is a prohibitively large amount of sequence for many reasonably chosen values of θ and N in forward simulations.
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Full-order finite element models of these structural components can require prohibitively large amounts of processor time.
In light of the minimum n-dimensional parameter space and the highly complicated nonlinear trajectories of the replicator equation coupled with mutation (Pais and Leonard 2011), such a model would require prohibitively large amounts of time series, rather than cross-sectional, data to be useful for inference.
Using gDNA allelic ratio as an internal control for mRNA imbalance is a more robust design, but obtaining this gDNA control for high-throughput sequencing data is, currently, prohibitively expensive owing to the very large amount of high-throughput resequencing needed to obtain high read depth for gDNA using whole genomes.
Such a large amount of data takes a prohibitively long time to print to the screen.
The large amount of power required by flooding causes a prohibitively short network lifetime, which makes it difficult to apply basic flooding protocol to real WSNs.
Note that the extension to a model where a user keeps track of coded packets and the associated vectors of coefficients, even if these cannot lead to decoding at the same time slot, is conceptually simple, but practically does not scale to a large amount of multicast sessions, as the dimension of the state space will be prohibitively large.
A large amount of bruising.
Get a large amount of toilet paper.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com