Risk assessment of complex mixtures is complicated by the wide variation in the composition of common mixtures, such as diesel exhaust, and the prohibitive expense of testing a virtually unlimited diversity of such mixtures (U.S. EPA 2001).
Due to the computationally prohibitive burden of testing all possible combination of RNA/miRNA/RNA triplets, the authors only considered those RNA/RNA pairs sharing a statistically significant number of common miRNAs, thus using some a priori information on putative or validated seeds to complementing expression data.
Evolving compound libraries are particularly suited for hit and lead finding in situations where resources are limited and the complete testing of a large screening compound collection is prohibitive.
Kathy Gerwig, vice president and environmental stewardship officer at Kaiser, said it would be financially prohibitive to test the toxicity of all its products.
Since this herbal preparation is ineligible for patenting, the prohibitive cost of systematic testing would effectively remove it from the market.
The prohibitive price of operational test beds means that computer simulations are the only viable solution for analysing the performance of different protocols and architectures.
"Realising that the prohibitive costs of current test equipment and technical expertise required meant that less than 5% of children were receiving these services made me look into exploring alternative solutions," he says.
That includes the prohibitive price of recommended comprehensive testing — now over $4,000 — and the availability of second opinions.
Although genetic interaction, expression profiling and chromatin binding approaches can provide lists of candidate TGs, they each suffer from disadvantages such as high cost, technical limitations, inability to detect direct TGs, and prohibitive numbers of conditions to test [6].
Instead of the current public-interest test of potentially anti-competitive policies, Labour promises a European-style "prohibitive approach" to "provide a strong deterrent against restrictive agreements and abuses of market power".
