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The resulting binary programming problem is shown to have a simple and global optimum solution but which also necessitates a prohibitive number of observation statistics.
Instead of simulating a prohibitive number of oscillators, our particle method simulates relatively few particles allowing for the efficient solution of the governing equation.
The first reason pertains to the fact that obtaining a significant frequency of appearance of such rare events would require a prohibitive number of simulation runs.
Indeed, a naive particle-based implementation is unable to explore the entire state-space without omission, unless a prohibitive number of particles is used.
This phenomenon prevents long enough coherent integration for low SNR targets to generate particles with significant weights, unless a prohibitive number of particles is employed.
This method employs the scattering phase functions directly, instead of expanding over their Legendre moments as in the original formulation, and hence is not compromised in cases where a prohibitive number of moments is required to maintain accuracy.
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Although genetic interaction, expression profiling and chromatin binding approaches can provide lists of candidate TGs, they each suffer from disadvantages such as high cost, technical limitations, inability to detect direct TGs, and prohibitive numbers of conditions to test [6].
While feasible for small numbers of raters, this procedure quickly becomes computationally prohibitive as the number of raters increases - for example, the exceedingly sparse single contingency table representing the breast cancer tumour data would have dimension 3732.
Since the computational complexity of the reconstruction problem is prohibitive when the number of gene transfers is large [34], we limited the Jungles reconciliation analysis to a maximum number of three gene transfers.
Even with powerful computers, maximum likelihood methods can be prohibitive if the number of taxa is large.
Still, the mp-MIQP complexity becomes quickly prohibitive as the number of faulty models increases.
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CEO of Professional Science Editing for Scientists @ prosciediting.com