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Due to the prohibitive computational time required for even a single heuristic search under the MP criterion, we employed the parsimony ratchet method [65]; this approach was implemented by means of the program PAUPRAT [66] using 500 repetitions and randomly perturbing 25% of the characters for each re-weighting.
In order to reduce the prohibitive computational time, migration estimates were carried out on a proportional sub-sampling of each cluster.
For example, it is impossible to apply standard implementations such as LIBSVM [ 9] and SVM light[ 10], because it requires prohibitive computational time and the size of the kernel matrix for compound-protein pairs is too huge to construct explicitly in the memory.
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Significant time was required for each reactor physics code calculation and because most of the solution individuals created by GAs result in unusable designs, analyzing every solutions involves prohibitive computational times.
However, some models, including detailed solute transport models, are further limited by prohibitive computation times.
The propagation of the trajectories of all the objects produced by a breakup would be prohibitive in terms of computational time; therefore, simplified models are needed to describe the consequences of a collision with a reasonable computational effort.
The combined method can considerably reduce the time-consuming VOF domain, and thus practically makes it possible to apply the VOF method for random wave calculations, in which long time computations are usually required to obtain statistically meaningful results, and therefore the use of the single-VOF model often becomes prohibitive in terms of computational time and storage memories.
Furthermore, since mapping accuracy depends on the length of the haplotype used in the study [ 14- 17], this computational time could become prohibitive when many markers are being considered.
A serious limitation of the compound-filling framework is that it is not suitable for predicting pathways for many compounds at a time owing to prohibitive computational cost.
However, the computational time required for this approach may be prohibitive in some situations [ 48, 49] and this method is unworkable when genotypic data are unavailable.
However, MCES computation is NP complete, and several heuristics have been proposed to reduce computational time, although computational time required for large chemical datasets is prohibitive.
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