Accurate simulation of radiation heat transfer inside a combustion chamber requires the line-by-line radiation model which is impossible for engineering practice because of the prohibitive computation time cost.
In general, exhaustively searching genomic space for knockout candidates is computationally intractable even on small-scale metabolic models (less than 100 reactions), much less on current genome-scale metabolic models (greater than 1000 reactions) due to prohibitive computation time.
For global tracking-by-detection, the main problem is to find a solution in a non-prohibitive computation time, because of the complexity of the possible detection combinations.
The computation of Green's functions is prohibitive in computation time terms [17], mostly for high-order equations, so it is necessary to find ways to palliate this problem.
The realization of such highly predictive behaviors for humanoid robots is a challenge because standard approaches, such as optimal control, result in computation times that are prohibitive for the predictive control of complex coordinated full-body movements over multiple steps.
Computation times are short.
The drawbacks of heuristic methods are: the quality of the solution cannot be guaranteed; and prohibitive computation efforts are required [22, 23, 24].
The resulting computation times are shown in Figure 8.
Although computation times were still feasible for the data presented here (~1 h on a standard PC), this method may be prohibitive for very large data sets.
This links the advantages of elementary mode analysis with the advantages of flux balance analysis, without requiring the prohibitive computation of all elementary modes.
