Sentence examples for prohibitive calculation from inspiring English sources
However, a classical optimization of the spot weld distribution using an exhaustive search approach is simply not feasible due to the very high order of the design space and the subsequently prohibitive calculation costs.
Although the significant advantage for the probability density function (PDF) methods of the exact treatment of chemical reactions in turbulent combustion problems, a detailed chemistry mechanism (e.g., the GRI mechanism) has not been implemented in the practical calculations by now due to the prohibitive computation of PDF methods.
Since the algorithm requires calculating the posterior of every possible class (in this case an utterance) given the data, exact calculation is prohibitive.
Thus an exact calculation is prohibitive for long motifs.
However, as more data becomes available and gene sets used for analysis become larger, such pair-based calculation becomes prohibitive.
As we discussed above, inferring the functional similarity of large gene sets using this calculation may become prohibitive.
With a "rule of thumb" type calculation, it is prohibitive to track these additional factors and perform the calculations they would entail by hand or using a non-programmable calculator.
Despite the advantages of our reported technique, there are also limitations of the study to note, aside from access to software to perform the templating and calculations, which may be prohibitive for some groups.
In practice exact calculation of this sum is prohibitive, hence one relies on approximating MCMC methods [ 8- 10].
For example, assuming spherical geometry, for a single degree of supercooling the critical radius of an ice embryo is about 518 Å containing approximately 18 million water molecules, which is currently computationally prohibitive to model (see 'Materials and methods' for calculation).
Using all deaths as an endpoint avoids these biases but leads to prohibitive sample sizes as shown in the following calculations based on a power of 80% and a one-sided type I error of 2.5%.
