Axitinib was given as 5 mg twice daily, with a provision for dose escalation to 10 mg twice daily in the absence of greater than grade 2 adverse effects, and in patients with no significant increase in blood pressure or hypertension, with a protocol amendment later introduced to prohibit dose escalation in patients receiving antihypertensive medications.
Some authors agreed with O'Connor to regard this time issue as being a part of clinical inertia and include it in the "Physician factors": " Providers often have competing interests, including lack of time, more urgent requests made by the patient, and practice habits that can prohibit the escalation of care when such a modification is clinically indicated.
Peripheral neuropathy prohibited dose escalation above 100 mg m−2, and grade 3 neuropathy was observed in two of 21 patients at ⩽100 mg m−2.
The PR104-docetaxel combination was evaluated further with the addition of prophylactic G-CSF as dose-limiting neutropenia prohibited dose escalation of PR-104 without haematological growth factor support.
(60 years old, grandmother) In this low-resource setting, people lack access to money and transportation that could quickly facilitate a higher level of care for their affected children; lack of funds prohibits timely escalation of care as guardians spend time raising money needed for the journey to Mbarara.
The rules of engagement stemming from the 2003 incident prohibit such police escalations like the one that led to Olsen's injury.
Overall, at DL 4, three of six patients experienced G4 granulocytopenia that demanded antibiotic treatment on the ward and prohibited a further escalation in dose.
Because its MTD was lower than the starting dose-level (400 mg/m) and severe (grade 3 and 4) neutropenia prohibited any dose-escalation, prophylactic G-CSF was added to the PR-104-docetaxel combination in the next combination group.
Because its MTD was lower that the starting dose-level (275 mg/m) and severe thrombocytopenia prohibited any dose-escalation, the PR-104-gemcitabine combination was not evaluated further.
And they prohibit abortions.
Many states, therefore, prohibit them.
