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We believe that this phenomenon is not easily explained with a single theory because the microenvironment progressively worsens in these patients.
Motor function, as measured in climbing assays, progressively worsens in these flies, an indicator of reduced neuronal function.
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The neck pain progressively worsened in intensity and was worse on turning his head to the right side.
Other symptoms were reduced cognitive functions, diffuse and severe livedo reticularis that persisted since she was a young adult (Fig. 1), and severe myalgias and mild stiffness that progressively worsened in the previous years.
Four months after the first surgery, she presented in our hospital a 1-month history of a breast tumor on her left chest wall, 1-week history of edema on her face and bilateral legs, dyspnea at rest, back pain, and declining of urine volume, all of which had progressively worsened in a few days.
The decreased cardiac function was progressively worsened in the vehicle-treated group.
Pt 03 progressively worsened in his quantitative and functional measures despite MAB infusions and in December 2011 lost ambulation.
These phenotypes progressively worsened in subsequent generations and their severity correlated with an increasing frequency of anaphase bridges in meiotic cells.
On the other hand, neurofibrillary tangles and neurodegeneration are believed to be downstream pathological events that progressively worsen in the presence of a relatively static total load of amyloid and which lead directly to cognitive impairment (Ingelsson et al., 2004; Jack et al., 2010).
The neurologic mutant mouse, oscillator, is characterized by a fine motor tremor and muscle spasms that begin at 2 weeks of age and progressively worsen, resulting in death by 3 weeks of age.
At a follow-up visit to the ED 2 days later, the patient complained of progressively worsening pain in his throat.
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