Interestingly, the global hypomethylation of DNA and histones has been shown to progressively increase in parallel with advanced grade and disease progression in human cancers (Kim et al, 1994; Qu et al, 1999; Soares et al, 1999; Piyathilake et al, 2001).
In spite of proper formation of polymerase complexes, the activity of RNPs including NLS mutations in PB2 was progressively reduced, in parallel to the decrease in their ability to interact with α-importin [10], as reflected in the activity of a CAT replicon in vivo (Fig. 2D).
Persuasive evidence includes the following: from day 3 to 7 post angioplasty, Smad3 levels progressively increase in parallel with VEGF in SMCs of the arterial media.
It has been demonstrated that Crn excretion progressively decreases in parallel with muscle wasting in patients with DMD [ 11], and 24-hour urinary Crn excretion may be a reliable index of muscle mass [ 12].
After one day in culture in the presence of DOXY, N1ICD expression was progressively reduced and in parallel, E-CADHERIN expression was increased throughout seven days of culture.
During OA, aggrecans are among the first matrix constituents to be affected, as they are progressively depleted from cartilage in parallel with the severity of the disease [ 23].
The incidence of AP has been progressively increasing in recent years in parallel with its risk factors such as duct obstruction by gallstones, alcohol abuse and obesity [ 2, 3].
Moreover, the pH values in the cell culture supernatant progressively decreased during cultivation time in parallel to an increasing cell number and reached a difference of about 0.15 pH values compared to control medium at the end of the cultivation (80% confluency) (Fig. 1A).
More importantly, results reported here revealed that excitability of BLA anxiety-related neurons increased progressively during repeated exposures to anxiety conditions; in parallel, the levels of anxiety also increased gradually (Figure 5).
In parallelizing, we assert these in parallel.
