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When the NOR task data are analyzed as a function of the D2 recognition index versus age of the animals, it is evident that APP/PS1 KI mice also become progressively impaired in this task as they age and the AD-relevant pathology progresses.
The capacity of the kidney to adjust to variation in intake of salt, potassium, and water becomes progressively impaired, so that electrolyte disturbances are common.
Advanced age is associated with progressively impaired innate and adaptive immunity [67].
The authors concluded that iron homeostasis within the PAG was persistently and progressively impaired in migraine patients.
Such quantitative muscle loss is associated with an increased echogenicity, possibly associated with progressively impaired muscle function.
As is known, fibrosis caused by cardiac fibroblasts is the major cause of cardiac remodeling after myocardial infarction [12] and progressively impaired ventricular function [20].
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It progressively impairs memory, judgment, decision-making and language.
Cerebral microhemorrhages (CMHs) are associated with rupture of small intracerebral vessels and are thought to progressively impair neuronal function.
It progressively impairs memory, judgment, decision-making and language (Nussbaum and Ellis, 2003; Goedert and Spillantini, 2006).
Additionally, we cannot exclude the possibility that ADMA might progressively impair β-cell function, another contributor to the development of type 2 diabetes [ 6- 9].
Human immunodeficiency virus (HIV) infection progressively impairs immune function, including that of the HIV-specific CD8+ T cells that partially control HIV replication.
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