Under supported conditions Parkinsonian subjects progressively failed to suppress MLRs and LLRs to perturbation (as it happened in controls) with increasing disease severity.
With increasing PDs, the fully protective closed-state telomere structure (possibly involving a t-loop) progressively fails to form, resulting in a structure that contributes to the integrated signal initiating onset of senescence while still protecting against fusion events.
Progressively, they fail to regulate body temperature, develop immune system impairments, and eventually die when their major organ systems begin to shut down.
When people lift light weights and fail to progressively increase the load, they only increase endurance, Dr. Kraemer said.
In summary, axon regeneration after peripheral nerve injury progressively fails due to chronic axotomy of the neurons and chronic Schwann cell denervation and is not due solely to irreversible atrophy of muscle as was previously believed [ 20].
While foscrb embryos proceed through DC, those expressing the foscrb Y10A variant progressively lose the AS and ultimately fail to complete DC (Video 2).
The law requires all students to reach proficiency in reading and math by 2014, and singles out schools that fail to make sufficient progress toward that goal for progressively more severe penalties.
However, a substantial proportion of patients expressing ER either fail to respond initially or become progressively resistant to endocrine therapies [ 3].
For example, mice with inactivation of perlecan, an ECM protein required for collagen fibril assembly, fail to organize cartilage growth plates after the mesenchymal condensation stage and the phenotype progressively worsens as development progresses.
However, a substantial proportion of patients (approximately 30-40 %) fail to respond to anti-TNF therapy, exposing them to unnecessary adverse effects as their disease progressively worsens [ 1, 4].
