Sentence examples for progressively downregulated from inspiring English sources
Notably, the transcriptomes of each differentiation stage differed significantly from each other and clustered readily apart, with large blocks of genes progressively downregulated, as well as blocks of genes that were upregulated over time, indicative of progressive changes in gene expression patterns during differentiation (Fig. 1f, Suppl. 3a).
Genes in cluster 1 of the k-means clustering (Figure 2) were progressively downregulated over time.
These genes were expressed in undifferentiated ES cells and were progressively downregulated as the level of Oct3/4 was repressed (Figure 2B).
During neuronal differentiation, REST is progressively downregulated at the protein level in neural precursors and at the mRNA level in post-mitotic neurons [23].
As shown in figure 3A, sik1 deficiency did not affect Oct-3/4 expression, which was progressively downregulated in both cell populations, nor Brachyury, which was nearly absent in the undifferentiated ES cells and transiently expressed during embryoid body formation peaking at day 4.
The two costimulatory molecules CD27 and CD28 are known to be progressively downregulated in CD8+ effector T cells.
An active mechanism which integrates stress conditions over time to progressively downregulate individual cells would represent an additional energetic burden and reduce population fitness.
This is particularly advantageous in the absence of an energy source, where an energy consuming regulatory mechanism to reliably sense and integrate environmental conditions over time and progressively downregulate individual cells, would represent an additional energetic burden.
We hypothesized that CTMP expression might progressively increase in ALS skeletal muscle as the disease progresses, downregulating Akt activity.
In these human skin SCC samples, miR-203 was already downregulated at the onset of tumorigenesis and progressively lost during the course of tumor progression, similar to the pattern observed in the mouse models.
As osteoblast maturation ensues, sp7-expressing cells downregulate Runx2, re-epithelialize by reforming adherens junctions, and progressively extend new mineralized bone.
