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Out of 3 episodic CH (ECH) patients, two had an improvement of bouts at 4 mg, but obtained a stable benefit at 6 mg; after the presumed end of their CH period they progressively discontinued the patches and the CH did not come back till the next cluster period.
These programs were progressively discontinued in Canada and in many other countries because they were not considered a cost-effective preventive measure [ 6– 9].
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In the 2nd line strategy, in the case of the combination of an oral antidepressant with an LAI SGA in the acute phase, it is recommended to optimize the dose of the LAI SGA and to progressively discontinue the oral antidepressant, depending on the clinical state.
In the case of the combination of an oral antipsychotic and an LAI antipsychotic in the acute phase, optimizing the dose of the LAI antipsychotic and progressively discontinuing the oral antipsychotic while monitoring the clinical state is recommended as the 1st line strategy.
All the previous therapies were progressively (2 months) discontinued.
Twelve hours after endoscopy, lidocaine was progressively reduced and discontinued.
Prednisone was promptly initiated in 2005 (1.5 mg/kg/day) and was progressively tapered and then discontinued in 2006.
When response occurs, the dose of PSL is tapered, and then the dose of CY is progressively decreased and eventually discontinued after 3 4 months from the time of normalization of haematocrit.
15 These preliminary observations were confirmed in a study of 10 septic shock patients in whom norepinephrine requirements were progressively reduced and eventually discontinued after an average of five daily CPFA sessions, 16 without adverse events.
Thiopentone infusion was progressively tapered over 24 hours and finally discontinued once therapeutic serum levels were achieved for these anti-epileptic medications.
Mitochondrial structural abnormalities are observable prior to the onset of glucose intolerance and progressively worsen with age even though nicotine exposure is discontinued at weaning.
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