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To mimic Purkinje network activation, the endocardium surface is then progressively activated from apex to base to produce a simulated activation sequence illustrated in Figure 1 A, in line with the experimental results by Durrer et al. The human AP model was modified to enable simulation of drug action on ICaL and IKr using the simple pore block model.
Previously, it had been shown that 5'AMP-activated protein kinase (AMPK) is progressively activated with prolonged cold exposure and that AMPK expression is significantly higher in BAT compared to WAT (Mulligan et al., 2007).
First, by allowing enough OGD exposure time for AD induction (Fig. 3) associated with a massive ionotropic glutamate receptor activation [32], we were able to record a progressively activated anion conductance with VRAC characteristics in the post-OGD stage.
Fibrinogen can be digested either by plasmin or by thrombin, and the activities of plasmin and thrombin are regulated or progressively activated by calcium ions; therefore, the changes in the calcium ion channels in the CaOx calculi may affect the fibrinolytic system.
In the next three steps (Fig. 2c e), consecutive electrodes in arc A are turned off one at a time while one additional electrode at the left on L2 is turned on so that 5 consecutive electrodes are progressively activated in order to achieve the arrangement as shown in Fig. 2e.
ladybird expression is progressively activated in myoblasts associated with the imaginal leg disc and precedes that of the founder cell marker dumbfounded.
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Subjecting the interface models to shear, our study reveals that mechanophores progressively activate as interfacial displacement increases starting with the mechanophores aligned along the direction of shear.
This experience is made even more intense with the integration of "Halo 3's" "skulls," which progressively activate as time goes on to alter the gameplay and up the challenge.
The mineralized amounts of CO2, deriving from both the photocatalytic oxidation itself and the external ambient, can progressively activate a chemical deterioration due to carbonation.
We found that BORIS progressively activates both promoters in these cells; thus, suggesting that BORIS can be a positive regulator of transcription of both genes.
The effect of membrane potential may be to increase the production of endogenous fatty acids or other molecules that progressively activate uncoupling, or to sensitize target proteins to the effects of generated or pre-existing activators such as products of reactive oxygen species.
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